APROL

The list of diseases is provided by the specialists of the site: https://pillintrip.com/medicine/aprol. Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, gouty arthritis, ankylosing spondyloarthritis (Behterev’s disease), osteoarthritis.

Pain syndrome: myalgia, ossalgia, neuralgia, arthralgia, radiculitis, headache and toothache, tendonitis, with cancer, post-traumatic and postoperative pain syndrome accompanied by inflammation, algodysmenorrhea, adnexitis, childbirth (as analgesic and tocolytic agent).

Infectious inflammatory diseases of the ENT organs with a pronounced pain syndrome (in the treatment): pharyngitis, tonsillitis, otitis media.

Fever syndrome with “colds” and infectious diseases.

Active substance, group
Naproxen, Nonsteroidal anti-inflammatory drug (NSAID)
Pharmaceutical form
Coated tablets, film-coated tablets

Contraindications
Hypersensitivity, erosive-ulcerative lesions of the gastrointestinal tract (in acute phase), “aspirin” triad (combination of bronchial asthma, recurrent polyposis of the nose and sinuses, intolerance to ASA and pyrazolone drugs), bone marrow inhibition, liver and/or kidney failure, pregnancy, lactation, children (under 1 year). Caution. CHF, children (under 16 years).

How to use: dosage and treatment course.
Inside. Tablets should be taken as a whole with fluids, you can take with a meal.

In the acute phase of the disease – 0.5-0.75 g 2 times a day. Maximum daily dose is 1.75 g. For maintenance therapy – in an average daily dose of 500 mg in 2 doses (in the morning and at night).

In acute attack of gout the first dose is 825 mg; then it is 275 mg every 8 hours.

In algodysmenorrhea, the first dose is 500 mg, then 275 mg every 6-8 hours for 3-4 days.

In migraine, 500 mg.

Rectal suppositories are usually administered at night (1 suppository of 0.5 g). If it is necessary to use naproxen in high doses, it is possible to combine the prescription in suppositories and in tablets.

For children aged 1-

5 years a daily dose of 2.5-5 mg/kg in 1-3 doses; the course of treatment should not exceed 14 days.

In juvenile arthritis in children over 5 years old the daily dose is 10 mg/kg. The preferred dosage form for children is a suspension.

Pharmacological action
It has anti-inflammatory, analgesic and antipyretic effects due to non-selective inhibition of COX1 and COX2 activity, which regulate Pg synthesis.

Side effects
NSAID gastropathy (gastric entral lesions in the form of mucosal erythema, hemorrhages, erosions and ulcers).

Nausea, vomiting, discomfort in epigastrium, skin rash, urticaria, angioedema; headache, drowsiness, tinnitus, dizziness, weakness, slowed reaction time; erosive and ulcerative lesions of other gastrointestinal tracts. gastrointestinal tract, bleeding and gastrointestinal perforations; eosinophilic pneumonia; thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia; hearing loss, renal or hepatic dysfunction.Overdose. Symptoms: heartburn, dyspepsia, nausea, vomiting, drowsiness.

Treatment: gastric lavage, activated charcoal – 0.5 g/kg. Dialysis is ineffective.

Special instructions
If it is necessary to determine 17-ketosteroids the drug should be discontinued 48 hours before the study. Liver and kidney functions and peripheral blood composition should be monitored. It should be taken into account that naproxen increases bleeding time.

Interaction
Simultaneous administration may cause decreased diuretic effect of furosemide; increased effect of indirect anticoagulants.

Increases toxicity of phenytoin, sulfonamides, methotrexate (blocks tubular secretion).

Reduces the hypotensive effect of beta-adrenoblockers.

Decreases the excretion of Li+ and increases its concentration in plasma.

Antacid drugs containing Mg2+ and Al3+ reduce absorption of naproxen.

Myelotoxic drugs increase manifestations of hematotoxicity of the drug.